Supramolecular Catalysis of Strecker Reaction in Water under Neutral Conditions in the Presence of β-Cyclodextrin
K. Surendra, N. Srilakshmi Krishnaveni, A. Mahesh and K. Rama Rao*
*Organic Chemistry Division-I, Indian Institute of Chemical Technology,
Hyderabad-500 007, India, Email: drkrrao
yahoo.com
K. Surendra, N. S. Krishnaveni, A. Mahesh, K. R. Rao, J. Org. Chem., 2006, 71, 2532-2534.
DOI: 10.1021/jo052510n
Abstract
An environmentally benign and highly efficient, biomimetic procedure for the
nucleophilic addition of trimethylsilyl cyanide to imines (Strecker reaction)
using β-cyclodextrin as a catalyst and water as solvent afforded
α-aminonitriles in quantitative
yields. The catalyst can be recycled a number of times without loss in activity.
see article for more examples
Key Words
Strecker Synthesis, α-Aminonitriles, Trimethylsilyl Cyanide
ID: J42-Y2006-810
