Structurally Well-Defined, Recoverable C₃-Symmetric Tris(β-hydroxy phosphoramide)-Catalyzed Enantioselective Borane Reduction of Ketones

Da-Ming Du,* Tao Fang, Jiaxi Xu and Shi-Wei Zhang

*Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China, Email: dudmpku.edu.cn

D.-M. Du, T. Fang, J. Xu, S.-W. Zhang, Org. Lett., 2006, 8, 1327-1330.

DOI: 10.1021/ol0600584

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Abstract

The catalytic asymmetric borane reduction of both electron-deficient and electron-rich ketones was achieved with high enantioselectivity with a C₃-symmetric chiral tris(β-hydroxy phosphoramide) ligand.

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Key Words

Reductions, Borane

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ID: J54-Y2006-800