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Direct Catalytic Intermolecular α-Allylic Alkylation of Aldehydes by Combination of Transition-Metal and Organocatalysis

Ismail Ibrahem, Armando Córdova*

*Department of Organic Chemistry, The Arrhenius Laboratory, Stockholm University, 106 91 Stockholm, Sweden, Email:

I. Ibrahem, A. Córdova, Angew. Chem. Int. Ed., 2006, 45, 1952-1956.

DOI: 10.1002/anie.200504021

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A simple method for the chemo- and regioselective, direct catalytic allylic alkylation of aldehydes and cyclic ketones has been developed. The combination of palladium and enamine catalysis furnished α-allylic alkylated aldehydes and cyclic ketones in high yields.

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Key Words

aldehydes, allylation, substituted alcohols, organocatalysis, sodium borohydride, Tsuji-Trost Reaction

ID: J06-Y2006-830