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Reusable and Efficient Pd(OAc)2/TBAB/PEG-400 System for Suzuki-Miyaura Cross-Coupling Reaction under Ligand-Free Conditions

Wen-Jie Liu, Ye-Xiang Xie, Yun Liang, Jin-Heng Li*

*College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, P. R. of China, Email:

W.-J. Liu, Y.-X. Xie, Y. Liang, J.-H. Li, Synthesis, 2006, 860-864.

DOI: 10.1055/s-2006-926323


The combination of Pd(OAc)2, TBAB and PEG-400 [poly(ethylene glycol-400)] was introduced as a reusable, ligand-free and efficient system for the Suzuki-Miyaura cross-coupling reaction. The coupling of a number of aryl halides with arylboronic acids afforded the corresponding products in moderate to excellent yields.

see article for more examples

Recyclable and Reusable Pd(OAc)2/DABCO/PEG-400 System for Suzuki-Miyaura Cross-Coupling Reaction

J.-H. Li, W.-J. Liu, Y.-X. Xie, J. Org. Chem., 2005, 70, 5409-5412.

Key Words

Pd(OAc)2, TBAB, PEG-400, Suzuki coupling, aryl halides, arylboronic acids, biaryls

ID: J66-Y2006-870