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On-Water Chemistry: Copper-Catalyzed Straightforward Synthesis of Benzo[b]furan Derivatives in Neat Water

Mónica Carril, Raul SanMartin,* Imanol Tellitu and Esther Domínguez

*Kimika Organikoa II Saila, Zientzia eta Teknologia Fakultatea, Euskal Herriko Unibertsitatea, P.O. Box 644, 48080 Bilbao, Spain, Email:

M. Carril, R. SanMartin, I. Tellitu, E. Dominguez, Org. Lett., 2006, 8, 1467-1470.

DOI: 10.1021/ol060274c (free Supporting Information)


Copper-TMEDA catalyzes the transformation of readily available ketone derivatives into the corresponding benzo[b]furans in good to excellent yields. The sustainable protocol uses water as the solvent without organic cosolvents, and one example of catalyst reutilization is also presented.

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ID: J54-Y2006-880