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Chemoenzymatic Dynamic Kinetic Resolution of Primary Amines

Jens Paetzold and Jan E. Bäckvall*

*Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE-10691 Stockholm, Sweden, Email:

J. Paetzold, J. E. Bäckvall, J. Am. Chem. Soc., 2005, 127, 17620-17621.

DOI: 10.1021/ja056306t


An efficient dynamic kinetic resolution of amines combines a ruthenium-catalyzed racemization with a lipase-catalyzed resolution. A variety of primary amines were transformed into one enantiomer of the amide in high yield and high enantioselectivity.

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Key Words

Acetylation, Amines

ID: J48-Y2005-2650