Chemoenzymatic Dynamic Kinetic Resolution of Primary Amines
Jens Paetzold and Jan E. Bäckvall*
*Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE-10691 Stockholm, Sweden, Email: jeborgan.su.se
J. Paetzold, J. E. Bäckvall, J. Am. Chem. Soc., 2005, 127, 17620-17621.
DOI: 10.1021/ja056306t (free Supporting Information)
An efficient dynamic kinetic resolution of amines combines a ruthenium-catalyzed racemization with a lipase-catalyzed resolution. A variety of primary amines were transformed into one enantiomer of the amide in high yield and high enantioselectivity.
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