Prevention of Undesirable Isomerization during Olefin Metathesis
Soon Hyeok Hong, Daniel P. Sanders, Choon Woo Lee, and Robert H. Grubbs*
*Arnold and Mabel Beckman Laboratory of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, Email: rhgcaltech.edu
S. H. Hong, D. P. Sander, C. W. Lee, R. H. Grubbs, J. Am. Chem. Soc., 2005, 127, 17160-17161.
DOI: 10.1021/ja052939w (free Supporting Information)
1,4-Benzoquinones have been found to prevent olefin isomerization of a number of allylic ethers and long-chain aliphatic alkenes during ruthenium-catalyzed olefin metathesis reactions. This mild, inexpensive, and effective method increases the overall product yield and purity.
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