Organic Chemistry Portal



Improved Procedure for Palladium-Catalyzed Hiyama Cross-Coupling Reaction of Aryl Halides with Aryltrimethoxysilanes under Solvent-Free Conditions

Jin-Heng Li*, Chen-Liang Deng, Ye-Xiang Xie

*Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research (Ministry of Education), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, China, Email:

J.-H. Li, C.-L. Deng, Y.-X. Xie, Synthesis, 2006, 969-974.

DOI: 10.1055/s-2006-926364


An efficient, solvent-free, palladium-catalyzed Hiyama cross-coupling reaction is reported. In the presence of PdCl2(MeCN)2, P(o-tol)3 and TBAF, a various aryl halides were coupled with arylsiloxanes to afford biaryls in moderate to excellent yields.

see article for more examples

Key Words

Hiyama coupling, aryl halides, arylsiloxanes

ID: J66-Y2006-930