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Gold(III) Salen Complex-Catalyzed Synthesis of Propargylamines via a Three-Component Coupling Reaction

Vanessa Kar-Yan Lo, Yungen Liu, Man-Kin Wong* and Chi-Ming Che*

*Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China, Email:,

V. K.-Y. Lo, Y. Liu, M.-K. Wong, C.-M. Che, Org. Lett., 2006, 8, 1529-1532.

DOI: 10.1021/ol0528641 (free Supporting Information)


Propargylamines have been synthesized by a gold(III) salen complex-catalyzed three-component coupling reaction of aldehydes, amines, and alkynes in water in excellent yields at 40C. With chiral prolinol derivatives as the amine component, excellent diastereoselectivities have been attained.

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Key Words

Propargylamines, Multicomponent Reactions

ID: J54-Y2006-990