Gold(III) Salen Complex-Catalyzed Synthesis of Propargylamines via a Three-Component Coupling Reaction
Vanessa Kar-Yan Lo, Yungen Liu, Man-Kin Wong* and Chi-Ming Che*
*Department of Chemistry and Open Laboratory of Chemical Biology of the
Institute of Molecular Technology for Drug Discovery and Synthesis, The
University of Hong Kong, Pokfulam Road, Hong Kong, China, Email: cmche
hku.hk,
mkwonghkusua.hku.hk
V. K.-Y. Lo, Y. Liu, M.-K. Wong, C.-M. Che, Org. Lett., 2006, 8, 1529-1532.
DOI: 10.1021/ol0528641
Abstract
Propargylamines have been synthesized by a gold(III) salen complex-catalyzed three-component coupling reaction of aldehydes, amines, and alkynes in water in excellent yields at 40°C. With chiral prolinol derivatives as the amine component, excellent diastereoselectivities have been attained.
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Key Words
Propargylamines, Multicomponent Reactions
ID: J54-Y2006-990
