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Regioselective Copper-Catalyzed Amination of Bromobenzoic Acids Using Aliphatic and Aromatic Amines

Christian Wolf,* Shuanglong Liu, Xuefeng Mei, Adam T. August, and Michael D. Casimir

*Department of Chemistry, Georgetown University, Washington, D.C. 20057, Email:

C. Wolf, S. Liu, X. Mei, A. T. August, M. D. Casimir, J. Org. Chem., 2006, 71, 3270-3273.

DOI: 10.1021/jo060034a (free Supporting Information)


A chemo- and regioselective copper-catalyzed amination of 2-bromobenzoic acids is described, which avoids the need for acid protection and produces N-aryl and N-alkyl anthranilic acid derivatives in good yield.

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Key Words

Ullmann Reaction, Amination

ID: J42-Y2006-1010