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New Air-Stable Catalysts for General and Efficient Suzuki-Miyaura Cross-Coupling Reactions of Heteroaryl Chlorides

Anil S. Guram,* Anthony O. King, John G. Allen, Xianghong Wang, Laurie B. Schenkel, Johann Chan, Emilio E. Bunel, Margaret M. Faul, Robert D. Larsen, Michael J. Martinelli and Paul J. Reider

*Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, Email: aguramamgen.com

A. S. Guram, A. O. King, J. G. Allen, X. Wang, L. B. Schenkel, J. Chan, E. E. Bunel, M. M. Faul, R. D. Larsen, M. J. Martinelli, P. J. Reider, Org. Lett., 2006, 8, 1787-1789.

DOI: 10.1021/ol060268g (free Supporting Information)


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Abstract

New air-stable palladium phosphine complexes represent simple, general, and efficient catalysts for the Suzuki-Miyaura cross-coupling of aryl halides including five-membered heteroaryl halides and heteroatom-substituted six-membered heteroaryl chlorides with a various arylboronic acids.

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New Catalysts for Suzuki-Miyaura Coupling Reactions of Heteroatom-Substituted Heteroaryl Chlorides

A. S. Guram, X. Wang, E. E. Bunel, M. M. Faul, R. D. Larsen, M. J. Martinelli, J. Org. Chem., 2007, 72, 5104-5112.


Key Words

Suzuki Coupling, Heterobiaryls


ID: J54-Y2006-1070