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Efficient Microwave Access to Polysubstituted Amidines from Imidoylbenzotriazoles

Alan R. Katritzky,* Chunming Cai and Sandeep K. Singh

*Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200, Email:

A. R. Katritzky, C. Cai, S. K. Singh, J. Org. Chem., 2006, 71, 3375-3380.

DOI: 10.1021/jo052443x

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Microwave reactions of primary and secondary amines with imidoylbenzotriazoles gave various polysubstituted amidines in good yields. Convenient preparations of a variety of amides and imidoylbenzotriazoles have also been developed using microwave irradiation under mild conditions and short reaction times.

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N-Acylbenzotriazoles:  Neutral Acylating Reagents for the Preparation of Primary, Secondary, and Tertiary Amides

A. R. Katritzky, H.-Y. He, K. Suzuki, J. Org. Chem., 2000, 65, 8210-8213.

Efficient Conversion of Carboxylic Acids into N-Acylbenzotriazoles

A. R. Katritzky, N. Kirichenko, B. V. Rogovoy, Synthesis, 2003, 2777-2780.

Key Words

Amides, Amidines, Microwave Synthesis

ID: J42-Y2006-1080