Microwave-Assisted Oxidative Aromatization of Hantzsch 1,4-Dihydropyridines using Manganese Dioxide
Mark C. Bagley*, M. Caterina Lubinu
*School of Chemistry, Main Building, Cardiff University, Park Place, Cardiff, CF10 3AT, UK, Email: Bagleymccardiff.ac.uk
M. C. Bagley, M. C. Lubinu, Synthesis, 2006, 1283-1288.
4-Substituted-1,4-dihydropyridines are readily and efficiently aromatized in only one minute using commercial manganese dioxide in the absence of an inorganic support at 100 °C under microwave irradiation. This rapid procedure gives the dehydrogenated or 4-dealkylated product in excellent yield.
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