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Direct, efficient, and inexpensive formation of α-hydroxyketones from olefins by hydrogen peroxide oxidation catalyzed by the 12-tungstophosphoric acid/cetylpyridinium chloride system

Yanfei Zhang, Zongxuan Shen, Jingting Tang, Yan Zhang, Lichun Kong and Yawen Zhang*

*Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineering, Suzhou University, Suzhou, 215123, China, Email:

Y. Zhang, Z. Shen, J. Tang, Y. Zhang, L. Kong, Y. Zhang, Org. Biomol. Chem., 2006, 4, 1478-1482.

DOI: 10.1039/b518200j

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A direct, mild ketohydroxylation of various 1-aryl-1-alkenes with H2O2, catalyzed by the inexpensive 12-tungstophosphoric acid/cetylpyridinium chloride system, gave acyloins in good yields and high regioselectivies.

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Key Words

α-hydroxyketones, hydrogen peroxide

ID: J52-Y2006-1000