Lactam Synthesis via the Intramolecular Hydroamidation of Alkynes Catalyzed by Palladium Complexes
Nitin T. Patil, Zhibao Huo, Gan B. Bajracharya and Yoshinori Yamamoto*
*Department of Chemistry, Graduate School of Science, Tohoku University,
Sendai 980-8578, Japan, Email: yoshi
mail.tains.tohoku.ac.jp
N. T. Patil, Z. Huo, G. B. Bajracharya, Y. Yamamoto, J. Org. Chem., 2006, 71, 3612-3614.
DOI: 10.1021/jo060142x
Abstract
A palladium-catalyzed intramolecular hydroamidation of amidoalkynes in 1,4-dioxane at 100°C gives lactams in good yields.
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Key Words
ID: J42-Y2006-1170
