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Lactam Synthesis via the Intramolecular Hydroamidation of Alkynes Catalyzed by Palladium Complexes

Nitin T. Patil, Zhibao Huo, Gan B. Bajracharya and Yoshinori Yamamoto*

*Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan, Email: yoshimail.tains.tohoku.ac.jp

N. T. Patil, Z. Huo, G. B. Bajracharya, Y. Yamamoto, J. Org. Chem., 2006, 71, 3612-3614.

DOI: 10.1021/jo060142x


Abstract

A palladium-catalyzed intramolecular hydroamidation of amidoalkynes in 1,4-dioxane at 100C gives lactams in good yields.

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Key Words

δ-lactams


ID: J42-Y2006-1170