Organic Chemistry Portal



(Bromodimethyl)sulfonium Bromide Catalyzed One-Pot Synthesis of α-Aminonitriles

Biswanath Das*, R. Ramu, B. Ravikanth, K. Ravinder Reddy

*Organic Chemistry Division I, Indian Institute of Chemical Technology, Hyderabad 500 007, India, Email:

B. Das, R. Ramu, B. Ravikanth, K. Ravinder Reddy, Synthesis, 2006, 1419-1422.

DOI: 10.1055/s-2006-926421


A novel, simple and efficient one-pot synthesis of α-aminonitriles has been achieved by a three-component condensation of carbonyl compounds, amines and trimethylsilyl cyanide in the presence of (bromodimethyl)sulfonium bromide as a catalyst at room temperature.

see article for more examples

Key Words

α-aminonitriles, carbonyl compounds, amines, trimethylsilyl cyanide, (bromodimethyl)sulfonium bromide, multicomponent reactions

ID: J66-Y2006-1180