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General Approach to the Coupling of Organoindium Reagents with Imines via Copper Catalysis

Daniel A. Black and Bruce A. Arndtsen*

*Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 2K6, Canada, Email: bruce.arndtsenmcgill.ca

D. A. Black, B. A. Arndtsen, Org. Lett., 2006, 8, 1991-1993.

DOI: 10.1021/ol060277p (free Supporting Information)


Abstract

A mild, versatile, copper-catalyzed three-component coupling of organoindium reagents with imines and acid chlorides provides α-substituted amides or N-protected amines in a single step with the sole byproduct being indium trichloride.

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Key Words

Benzylamines, Alkylamines, Amides, Carbamates, Multicomponent Reactions


ID: J54-Y2006-1190