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(IPr)Pd(acac)Cl: An Easily Synthesized, Efficient, and Versatile Precatalyst for C-N and C-C Bond Formation

Nicolas Marion, Elise C. Ecarnot, Oscar Navarro, Dino Amoroso, Andrew Bell and Steven P. Nolan*

*School of Chemistry, University of St Andrews, St Andrews KY16 9ST, U.K., Email: sn17st-andrews.ac.uk

N. Marion, E. C. Ecarnot, O. Navarro, D. Amoroso, A. Bell, S. P. Nolan, J. Org. Chem., 2006, 71, 3816-3821.

DOI: 10.1021/jo060190h (free Supporting Information)


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Abstract

The complex (IPr)Pd(acac)Cl has proven to be a highly active PdII precatalyst in Buchwald-Hartwig reactions and α-ketone arylations of a wide range of substrates including unactivated, sterically hindered, and heterocyclic aryl chlorides.

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General and Efficient Catalytic Amination of Aryl Chlorides Using a Palladium/Bulky Nucleophilic Carbene System

J. Huang, G. Grasa, S. P. Nolan, Org. Lett., 1999, 1, 1307-1309.

Modified (NHC)Pd(allyl)Cl (NHC = N-Heterocyclic Carbene) Complexes for Room-Temperature Suzuki-Miyaura and Buchwald-Hartwig Reactions

N. Marion, O. Navarro, J. Mei, E. D. Stevens, N. M. Scott, S. P. Nolan, J. Am. Chem. Soc., 2006, 128, 4101-4111.

Cross-Coupling and Dehalogenation Reactions Catalyzed by (N-Heterocyclic carbene)Pd(allyl)Cl Complexes

O. Navarro, H. Kaur, P. Mahjoor, S. P. Nolan, J. Org. Chem., 2004, 69, 3173-3180.


Key Words

Buchwald-Hartwig Coupling, α-Arylation


ID: J42-Y2006-1210