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Silicasulfuric Acid/NaNO3 as a New Reagent for the Deprotection of S,S-Acetals under Mild Conditions

Abdol R. Hajipour*, Amin Zarei, Leila Khazdooz, Arnold E. Ruoho

*Pharmaceutical Research Laboratory, College of Chemistry, Isfahan University of Technology, Isfahan 84156, Iran, Email:

A. R. Hajipour, A. Zarei, L. Khazdooz, A. E. Ruoho, Synthesis, 2006, 1480-1484.

DOI: 10.1055/s-2006-926431


An efficient, mild and chemoselective method for the deprotection of S,S-acetals to the corresponding carbonyl compounds using silicasulfuric acid/NaNO3 is reported.

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proposed mechanism

Key Words

silica sulfuric acid, sodium nitrate, deprotection, S,S-acetals

ID: J66-Y2006-1230