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A Highly Active Catalyst for Suzuki-Miyaura Cross-Coupling Reactions of Heteroaryl Compounds

Kelvin L. Billingsley, Kevin W. Anderson, Stephen L. Buchwald*

*Department of Chemistry, Room 18-490, Massachusetts Institute of Technology, Cambridge, MA 02139, Email:

K. L. Billingsley, K. W. Anderson, S. L. Buchwald, Angew. Chem. Int. Ed., 2006, 45, 3484-3488.

DOI: 10.1002/anie.200600493 (free Supporting Information)


Highly stable and active Pd-phosphine catalysts have been found for the Suzuki-Miyaura coupling of pyridine, pyrrole, and indole boronic acids. These complexes are not inhibited by the presence of highly basic aminopyridines or aminopyrimidines.

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Key Words

Suzuki Coupling, Heterobiaryls

ID: J06-Y2006-1300