Synthesis of Highly Substituted Pyrroles via a Multimetal-Catalyzed Rearrangement-Condensation-Cyclization Domino Approach
Jörg T. Binder and Stefan F. Kirsch*
*Department Chemie, Technische Universität München, Lichtenbergstrasse 4, 85747 Garching, Germany, Email: stefan.kirschch.tum.de
J. T. Binder, S. F. Kirsch, Org. Lett., 2006, 8, 2151-2153.
DOI: 10.1021/ol060664z
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Abstract
Propargyl vinyl ethers and aromatic amines are effectively converted into tetra- and pentasubstituted 5-methylpyrroles through a silver(I)-catalyzed propargyl-Claisen rearrangement, an amine condensation, and a gold(I)-catalyzed 5-exo-dig heterocyclization in a convenient one-pot process.
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Gold(I)-Catalyzed Synthesis of Highly Substituted Furans
M. H. Suhre, M. Reif, S. F. Kirsch, Org. Lett., 2005, 7, 3873-3876.
Key Words
Pyrroles, Claisen rearrangement
ID: J54-Y2006-1340