Low Ligand Loading, Highly Enantioselective Addition of Phenylacetylene to Aromatic Ketones Catalyzed by Schiff-Base Amino Alcohols
Chao Chen, Liang Hong, Zhao-Qing Xu, Lei Liu and Rui Wang*
*Department of Biochemistry and Molecular Biology, School of Life Sciences,
Lanzhou University, Lanzhou, Gansu 730000, China, Email: wangrui
lzu.edu.cn
C. Chen, L. Hong, Z.-Q. Xu, L. Liu, R. Wang, Org. Lett., 2006, 8, 2277-2280.
DOI: 10.1021/ol060526+
Abstract
Schiff-base amino alcohols derived from L-phenylglycine are highly effective ligands for the enantioselective addition of phenylacetylene to aromatic ketones to give optically active tertiary propargylic alcohols.
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Key Words
ID: J54-Y2006-1390
