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Enantioselective One-Pot Three-Component Synthesis of Propargylamines

Alakesh Bisai and Vinod K. Singh*

*Department of Chemistry, Indian Institute of Technology, Kanpur, India 208 016, Email: vinodksiitk.ac.in

A. Bisai, V. K. Singh, Org. Lett., 2006, 8, 2405-2408.

DOI: 10.1021/ol060793f


Abstract

A copper(I) complex of i-Pr-pybox-diPh efficiently catalyzes the enantioselective one-pot three-component synthesis of propargylamines from aromatic aldehydes, anilines, and alkynes. A transition-state model has been proposed.

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Key Words

Propargylic Amines, Multicomponent Reactions


ID: J54-Y2006-1420