Axially Chiral Guanidine as Enantioselective Base Catalyst for 1,4-Addition Reaction of 1,3-Dicarbonyl Compounds with Conjugated Nitroalkenes
Masahiro Terada,* Hitoshi Ube, and Yusuke Yaguchi
*Department of Chemistry, Graduate School of Science, Tohoku University,
Sendai 980-8578, Japan, Email: mterada
mail.tains.tohoku.ac.jp
M. Terada, H. Ube, Y. Yaguchi, J. Am. Chem. Soc., 2006, 128, 1454-1455.
DOI: 10.1021/ja057848d
Abstract
An axially chiral guanidine catalyst facilitated the highly enantioselective 1,4-addition reaction of 1,3-dicarbonyl compounds with a broad range of conjugated nitroalkenes and showed extremely high catalytic activity.
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Key Words
Michael Addition, Organocatalysis, Nitro Compounds
ID: J48-Y2006-1430
