Ir- and Ru-Catalyzed Sequential Reactions: Asymmetric α-Alkylative Reduction of Ketones with Alcohols
Gen Onodera, Yoshiaki Nishibayashi*, Sakae Uemura
*Institute of Engineering Innovation, The University of Tokyo, Yayoi,
Bunkyo-ku, Tokyo, 113-8656, Japan, Email: ynishiba
sogo.t.u-tokyo.ac.jp
G. Onodera, Y. Nishibayashi, S. Uemura, Angew. Chem. Int. Ed., 2006, 45, 3819-3822.
DOI: 10.1002/anie.200600677
Abstract
An asymmetric α-alkylative reduction of prochiral ketones with primary alcohols has been disclosed. The reaction is catalyzed by both iridium and ruthenium complexes and gave optically active alcohols with elongation of the carbon skeleton with high enantioselectivity.
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possible reaction pathway
Key Words
alkylation, homogeneous catalysis, iridium, reduction, ruthenium, isopropanol
ID: J06-Y2006-1480
