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Ir- and Ru-Catalyzed Sequential Reactions: Asymmetric α-Alkylative Reduction of Ketones with Alcohols

Gen Onodera, Yoshiaki Nishibayashi*, Sakae Uemura

*Institute of Engineering Innovation, The University of Tokyo, Yayoi, Bunkyo-ku, Tokyo, 113-8656, Japan, Email:

G. Onodera, Y. Nishibayashi, S. Uemura, Angew. Chem. Int. Ed., 2006, 45, 3819-3822.

DOI: 10.1002/anie.200600677 (free Supporting Information)


An asymmetric α-alkylative reduction of prochiral ketones with primary alcohols has been disclosed. The reaction is catalyzed by both iridium and ruthenium complexes and gave optically active alcohols with elongation of the carbon skeleton with high enantioselectivity.

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possible reaction pathway

Key Words

alkylation, homogeneous catalysis, iridium, reduction, ruthenium, isopropanol

ID: J06-Y2006-1480