N,N-Dimethyl-β-alanine as an Inexpensive and Efficient Ligand for Palladium-Catalyzed Heck Reaction
Xin Cui, Zhe Li, Chuan-Zhou Tao, Yu Xu, Juan Li, Lei Liu* and Qing-Xiang Guo*
*Department of Chemistry, University of Science and Technology of China, Hefei 230026, China, Email: leiliuustc.edu.cn, qxguoustc.edu.cn
X. Cui, Z. Li, C.-Z. Tao, Y. Xu, J. Li, L. Liu, Q.-X. Guo, Org. Lett., 2006, 8, 2467-2470.
N,N-Dimethyl-β-alanine is a more powerful phosphine-free ligand than the previously reported ligand, N,N-dimethylglycine in the Pd-catalyzed Heck reaction of various aryl bromides, aryl iodides, and activated aryl chlorides. Kinetic and theoretical studies are discussed.
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X. Cui, J. Li, Z.-P. Zhang, Y. Fu, L. Liu, Q.-X. Guo, J. Org. Chem., 2007, 72, 9342-9345.