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A General and Long-Lived Catalyst for the Palladium-Catalyzed Coupling of Aryl Halides with Thiols

Manuel A. Fernández-Rodríguez, Qilong Shen and John F. Hartwig*

*Department of Chemistry, Yale University, PO Box 208107 New Haven, Connecticut 06520-8107, Email:

M. A. Fernández-Rodríguez, Q. Shen, J. F. Hartwig, J. Am. Chem. Soc., 2006, 128, 2180-2181.

DOI: 10.1021/ja0580340

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A general palladium-catalyzed reaction using the CyPF-t-Bu ligand for the coupling of aryl halides and sulfonates with thiols exhibits extraordinary turnover numbers and high tolerance of functional groups.

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Key Words

aryl sulfides

ID: J48-Y2006-1610