Useful Reagents for Introduction of Boc and Fmoc Protective Groups to Amines: Boc-DMT and Fmoc-DMT
Kazuhito Hioki, Mizuho Kinugasa, Michiko Kishimoto, Miho Fujiwara, Shohei Tani, Munetaka Kunishima*
*Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Nishiku, Kobe 651-2180, Japan, Email: kunisimapharm.kobegakuin.ac.jp
K. Hioki, M. Kinugasa, M. Kishimoto, M. Fujiwara, S. Tani, M. Kunishima, Synthesis, 2006, 1931-1933.
New, stable amino-protecting reagents, Boc-DMT and Fmoc-DMT, were prepared, and found to be useful for the introduction of Boc and Fmoc groups into amines. Both the reagents can protect various amines including amino acids in good yield in aqueous media.
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protecting groups, amines, amino acids, triazine, active carbonate ester, Boc-protected amino groups, Fmoc-protected amino groups