Enantioselective, Palladium-Catalyzed α-Arylation of N-Boc-pyrrolidine
Kevin R. Campos,* Artis Klapars, Jacob H. Waldman, Peter G. Dormer and Cheng-yi Chen
*Department of Process Research, Merck Research Laboratories, P.O. Box 2000,
Rahway, New Jersey 07065, Email: kevin_campos
merck.com
K. R. Campos, A. Klapars, J. H. Waldman, P. G. Dormer, C.-Y. Chen, J. Am. Chem. Soc., 2006, 128, 3538-3539.
DOI: 10.1021/ja0605265
Abstract
An enantioselective Pd-catalyzed α-arylation of N-Boc-pyrrolidine, which relies on Beak's sparteine-mediated, enantioselective deprotonation of N-Boc-pyrrolidine, forms a broad range of 2-aryl-N-Boc-pyrrolidines in high enantiomeric ratio.
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Key Words
Negishi Coupling, Pyrrolidines
ID: J48-Y2006-1680
