Significantly Improved Method for the Pd-Catalyzed Coupling of Phenols with Aryl Halides: Understanding Ligand Effects
Carlos H. Burgos, Timothy E. Barder, Xiaohua Huang, Stephen L. Buchwald*
*Department of Chemistry, Room 18-490, Massachusetts Institute of Technology, Cambridge, MA 02139, USA, Email: sbuchwalmit.edu
C. H. Burgos, T. E. Barder, X. Huang, S. L. Buchwald, Angew. Chem. Int. Ed., 2006, 45, 4321-4326.
see article for more reactions
The scope and generality of Pd-catalyzed diaryl ether formation has been improved allowing the coupling of electron-deficient aryl halides almost without any restrictions. The role of the ligand bulk in these C-O bond-forming reactions is discussed.
see article for more reactions and examples
Buchwald-Hartwig coupling, diaryl ethers, biaryl phosphines, C-O bond formation, palladium, substituent effects, synthetic methods