Strecker Reaction of Aldimines Catalyzed by a Nucleophilic N-Heterocyclic Carbene

Yoshimasa Fukuda, Yuka Maeda, Kazuhiro Kondo*, Toyohiko Aoyama*

*Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan, Email: kazukphar.nagoya-cu.ac.jp, aoyamaphar.nagoya-cu.ac.jp

Y. Fukuda, Y. Maeda, K. Kondo, T. Aoyama, Synthesis, 2006, 1937-1939.

DOI: 10.1055/s-2006-942376

---

see article for more reactions

Abstract

The first method for Strecker reaction of aldimines with TMSCN in the presence of a N-heterocyclic carbene as a nucleophilic catalyst is described.

see article for more examples

---

---

Key Words

Strecker Reaction, Organocatalysis, Aldimines, N-Heterocyclic Carbenes, Imidazolium Salts, Cyanation

---

ID: J66-Y2006-1720