A Simple Catalytic Method for the Regioselective Halogenation of Arenes
Dipannita Kalyani, Allison R. Dick, Waseem Q. Anani and Melanie S. Sanford*
*University of Michigan, Department of Chemistry, 930 North University
Avenue, Ann Arbor, Michigan 48109-1055, Email: mssanfor
umich.edu
D. Kalyani, A. R. Dick, W. Q. Anani, M. S. Sanford, Org. Lett., 2006, 8, 2523-2526.
DOI: 10.1021/ol060747f
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Abstract
Mild palladium-catalyzed, regioselective chlorinations, brominations, and iodinations of arene C-H bonds using N-halosuccinimides as oxidants are described. These transformations can provide products that are complementary to those obtained via conventional electrophilic aromatic substitution reactions.
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Key Words
Bromination, Chlorination, Iodination, NCS
ID: J54-Y2006-1730
