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Proline/Pipecolinic Acid-Promoted Copper-Catalyzed P-Arylation

Cheng Huang, Xu Tang, Hua Fu,* Yuyang Jiang and Yufen Zhao

*Key Laboratory of Chemical Biology, Guangdong Province, Graduate School of Shenzhen, Tsinghua University, Shenzhen 518057, P. R. China, Email:

C. Huang, X. Tang, H. Fu, Y. Jiang, Y. Zhao, J. Org. Chem., 2006, 71, 5020-5022.

DOI: 10.1021/jo060492j (free Supporting Information)


A convenient and efficient copper-catalyzed approach for P-arylation of organophosphorus compounds containing P-H uses the commercially available and inexpensive proline and pipecolinic acid as ligands. The method can provide an entry to arylphosphonates, arylphosphinates and arylphosphine oxides.

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Key Words

phosphonates, phosphinates, phosphine oxides

ID: J42-Y2006-1750