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A Facile Synthesis of 1-Substituted-1H-1,2,3,4-Tetrazoles Catalyzed by Ytterbium Triflate Hydrate

Wei-Ke Su*, Zhi Hong, Wei-Guang Shan, Xing-Xian Zhang

*Zhejiang Key Laboratory of Pharmaceutical Engineering, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, 310014, P.R. China, Email:

W.-K. Su, Z. Hong, W.-G. Shan, X.-X. Zhang, Eur. J. Org. Chem., 2006, 2723-2726.

DOI: 10.1002/ejoc.200600007


A series of 1-substituted 1H-1,2,3,4-tetrazole compounds have been synthesized in good yields from amines, triethyl orthoformate, and sodium azide through the catalyzed reaction with Yb(OTf)3. Some of the 1-susbstituted 1H-1,2,3,4-tetrazole compounds showed strong phytocidal activity.

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Key Words

Lanthanides, Catalyst, Tetrazoles, Cyclization

ID: J24-Y2006-1800