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Synthesis of Substituted Pyridine Derivatives via the Ruthenium-Catalyzed Cycloisomerization of 3-Azadienynes

Mohammad Movassaghi* and Matthew D. Hill

*Massachusetts Institute of Technology, Department of Chemistry, Cambridge, Massachusetts 02139, Email:

M. Movassaghi, M. D. Hill, J. Am. Chem. Soc., 2006, 128, 4592-4593.

DOI: 10.1021/ja060626a


The direct conversion of amides, including sensitive N-vinyl amides, to the corresponding trimethylsilyl alkynyl imines followed by a ruthenium-catalyzed protodesilylation and cycloisomerization gives various substituted pyridines and quinolines.

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Single-Step Synthesis of Pyridine Derivatives

M. Movassaghi, M. D. Hill, O. K. Ahmad, J. Am. Chem. Soc., 2007, 129, 10096-10097.

Key Words

Imines, Pyridines, Quinolines

ID: J48-Y2006-1880