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Highly Enantioselective Addition of Me2Zn to Aldehydes Catalyzed by ClCr(Salen)

Pier Giorgio Cozzi* and Peter Kotrusz

*Dipartimento di Chimica, University of Bologna, "G. Ciamician", via Selmi 2, 40126 Bologna, Italy, Email:

P. G. Cozzi, P. Kotrusz, J. Am. Chem. Soc., 2006, 128, 4940-4941.

DOI: 10.1021/ja057969d


Simple procedure, room temperature, and low catalyst loading are the characteristics of a new ClCr(Salen)-catalyzed enantioselective 1,2-addition of the rather unreactive Me2Zn to a broad range of aldehydes.

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ID: J48-Y2006-1900