Palladium-Catalyzed Intermolecular α-Arylation of Zinc Amide Enolates under Mild Conditions
Takuo Hama, Darcy A. Culkin and John F. Hartwig*
*Department of Chemistry, Yale University, P.O. Box 208107, New Haven,
Connecticut 06520-8107, Email: john.hartwig
yale.edu
T. Hama, D. A. Culkin, J. F. Hartwig, J. Am. Chem. Soc., 2006, 128, 4976-4985.
DOI: 10.1021/ja056076i
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Abstract
The use of zinc enolates (isolated Reformatsky reagents or generated in situ from α-bromo amides or lithium enolates) instead of alkali metal enolates, greatly expands the scope of the palladium-catalyzed α-arylation of aryl bromides and vinyl bromides.
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Key Words
ID: J48-Y2006-1940
