Organic Chemistry Portal



Palladium-Catalyzed Intermolecular α-Arylation of Zinc Amide Enolates under Mild Conditions

Takuo Hama, Darcy A. Culkin and John F. Hartwig*

*Department of Chemistry, Yale University, P.O. Box 208107, New Haven, Connecticut 06520-8107, Email:

T. Hama, D. A. Culkin, J. F. Hartwig, J. Am. Chem. Soc., 2006, 128, 4976-4985.

DOI: 10.1021/ja056076i (free Supporting Information)

see article for more examples


The use of zinc enolates (isolated Reformatsky reagents or generated in situ from α-bromo amides or lithium enolates) instead of alkali metal enolates, greatly expands the scope of the palladium-catalyzed α-arylation of aryl bromides and vinyl bromides.

see article for more reactions

see article for more examples

Key Words


ID: J48-Y2006-1940