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Palladium-Catalyzed Intermolecular α-Arylation of Zinc Amide Enolates under Mild Conditions

Takuo Hama, Darcy A. Culkin and John F. Hartwig*

*Department of Chemistry, Yale University, P.O. Box 208107, New Haven, Connecticut 06520-8107, Email: john.hartwigyale.edu

T. Hama, D. A. Culkin, J. F. Hartwig, J. Am. Chem. Soc., 2006, 128, 4976-4985.

DOI: 10.1021/ja056076i (free Supporting Information)



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Abstract

The use of zinc enolates (isolated Reformatsky reagents or generated in situ from α-bromo amides or lithium enolates) instead of alkali metal enolates, greatly expands the scope of the palladium-catalyzed α-arylation of aryl bromides and vinyl bromides.

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Key Words

α-Arylation


ID: J48-Y2006-1940