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Gold-Catalyzed Intramolecular Carbothiolation of Alkynes: Synthesis of 2,3-Disubstituted Benzothiophenes from (α-Alkoxy Alkyl) (ortho-Alkynyl Phenyl) Sulfides

Itaru Nakamura*, Takuma Sato, Yoshinori Yamamoto

*Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan, Email:

I. Nakamura, T. Sato, Y. Yamamoto, Angew. Chem. Int. Ed., 2006, 45, 4473-4475.

DOI: 10.1002/anie.200601178


A gold-catalyzed carbothiolation provided an atom-economic way of synthesizing sulfur-containing heterocycles such as 2,3-disubstituted benzothiophenes.

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Key Words

cyclization, gold, homogeneous catalysis, benzothiophenes, synthetic methods

ID: J06-Y2006-1690