Amino Alcohols as Ligands for Nickel-Catalyzed Suzuki Reactions of Unactivated Alkyl Halides, Including Secondary Alkyl Chlorides, with Arylboronic Acids
Francisco González-Bobes and Gregory C. Fu*
*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Email: gcfmit.edu
F. González-Bobes, G. C. Fu, J. Am. Chem. Soc., 2006, 128, 5360-5361.
DOI: 10.1021/ja0613761 (free Supporting Information)
Suzuki cross-coupling reactions of an unprecedented array of unactivated primary and secondary alkyl halides with arylboronic acids can be accomplished through the use of nickel/amino alcohol-based catalysts. Both the nickel precatalysts and the amino alcohols are commcercially available and air-stable.
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