Reconstructed Hydrotalcite as a Highly Active Heterogeneous Base Catalyst for Carbon-Carbon Bond Formations in the Presence of Water

Kohki Ebitani, Ken Motokura, Kohsuke Mori, Tomoo Mizugaki and Kiyotomi Kaneda*

*Department of Materials Engineering Science, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka 560-8531, Japan, Email: kanedacheng.es.osaka-u.ac.jp

K. Ebitani, K. Motokura, K. Mori, T. Mizugaki, K. Kaneda, J. Org. Chem., 2006, 71, 5440-5447.

DOI: 10.1021/jo060345l

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Abstract

Aldol, Knoevenagel, and Michael reactions of carbonyl compounds are efficiently catalyzed in the presence of water by reconstructed hydrotalcites as solid base catalysts, obtained by treating Mg-Al mixed oxide with water. Reconstructed hydrotalcites provide a unique acid-base bifunctional surface.

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Highly Efficient C-C Bond-Forming Reactions in Aqueous Media Catalyzed by Monomeric Vanadate Species in an Apatite Framework

T. Hara, S. Kanai, K. Mori, T. Mizugaki, K. Ebitani, K. Jitsukawa, K. Kaneda, J. Org. Chem., 2006, 71, 7455-7462.

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Key Words

Aldol Addition, Knoevenagel Condensation, Michael Addition

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ID: J42-Y2006-2030