Pd/C-Catalyzed Chemoselective Hydrogenation in the Presence of Diphenylsulfide

Akinori Mori, Yumi Miyakawa, Eri Ohashi, Tomoko Haga, Tomohiro Maegawa and Hironao Sajiki*

*Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, Mitahora-higashi, Gifu 502-8585, Japan, Email: sajikigifu-pu.ac.jp

A. Mori, Y. Miyakawa, E. Ohashi, T. Haga, T. Maegawa, H. Sajiki, Org. Lett., 2006, 8, 3279-3281.

DOI: 10.1021/ol061147j

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Abstract

A Pd/C-catalyzed hydrogenation using diphenylsulfide as a catalyst poison selectively reduces olefin and acetylene functionalities without hydrogenolysis of aromatic carbonyls and halogens, benzyl esters, and N-Cbz protective groups.

see article for more examples

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Highly chemoselective hydrogenation method using novel finely dispersed palladium catalyst on silk-fibroin: its preparation and activity

T. Ikawa, H. Sajiki, K. Hirota, Tetrahedron, 2005, 61, 2217-2231.

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Key Words

Hydrogenation (alkenes, alkynes, α,β-unsaturated compounds), Hydrogen

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ID: J54-Y2006-2080