Phosphine-Free Cross-Coupling Reaction of Arylboronic Acids with Carboxylic Anhydrides or Acyl Chlorides in Aqueous Media

Bingwei Xin, Yuhong Zhang* and Kai Cheng

*Department of Chemistry, Zhejiang University, Hangzhou 310027, P.R. China, Email: yhzhangzjuem.zju.edu.cn

B. Xin, Yuhong Zhang, K. Cheng, J. Org. Chem., 2006, 71, 5725-5731.

DOI: 10.1021/jo060749d

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Abstract

The palladium acetate-catalyzed coupling reaction of aryl boronic acids with carboxylic anhydrides or acyl chlorides was carried out smoothly in water in the presence of PEG or [bmim][PF₆] to give high yields of ketones. The Pd(OAc)₂-H₂O-[bmim][PF₆] catalytic system can be recovered and reused.

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The Surfactant-Promoted Cross-Coupling Reactions of Arylboronic Acids with Carboxylic Anhydrides or Acyl Chlorides in Water

B. Xin, Y. Zhang, K. Cheng, Synthesis, 2007, 1970-1978.

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Key Words

Acylation, Ionic Liquids, Green Chemistry

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ID: J42-Y2006-2130