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HClO4-SiO2 as a new, highly efficient, inexpensive and reusable catalyst for N-tert-butoxycarbonylation of amines

Asit K. Chakraborti and Sunay V. Chankeshwara

*Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S. A. S. Nagar 160 062, Punjab, India, Email:

A. K. Chakraborti, S. V. Chankeshwara, Org. Biomol. Chem., 2006, 4, 2769-2771.

DOI: 10.1039/b605074c (free Supporting Information)


Perchloric acid adsorbed on silica-gel (HClO4-SiO2) was found to be a new, highly efficient, inexpensive and reusable catalyst for chemoselective N-tert-butoxycarbonylation of amines at room temperature and under solvent-free conditions.

see article for more examples

Catalyst-Free Chemoselective N-tert-Butyloxycarbonylation of Amines in Water

S. V. Chankeshwara, A. K. Chakraborti, Org. Lett., 2006, 8, 3259-3262.

Perchloric Acid Adsorbed on Silica Gel (HClO4-SiO2) as an Extremely Efficient and Reusable Catalyst for 1,3-Dithiolane/Dithiane Formation

S. Rudrawar, R. C. Besra, A. K. Chakraborti, Synthesis, 2006, 2767-2771.

Key Words

tert-butyl carbamates, green chemistry

ID: J52-Y2006-2160