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Palladium(0)-Catalyzed Suzuki-Miyaura Cross-Coupling Reactions of Potassium Aryl- and Heteroaryltrifluoroborates with Alkenyl Bromides

Gary A. Molander* and Tiziano Fumagalli

*Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, Email: gmolandrsas.upenn.edu

G. A. Molander, T. Fumagalli, J. Org. Chem., 2006, 71, 5743-5747.

DOI: 10.1021/jo0608366 (free Supporting Information)


Abstract

Efficient, stereospecific palladium(0)-catalyzed Suzuki-Miyaura cross-couplings of potassium aryl- and heteroaryltrifluoroborates with alkenyl bromides can generally be carried out using 2 mol % of palladium catalyst and 3 equiv of base in toluene/H2O.

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Suzuki-Miyaura Cross-Coupling Reactions of Potassium Alkenyltrifluoroborates

G. A. Molander, C. R. Bernardi, J. Org. Chem., 2002, 67, 8424-8429.


Key Words

Suzuki Coupling, Olefination, Potassium Trifluoroborates


ID: J42-Y2006-2200