Organic Chemistry Portal



Palladium-Catalyzed Oxidation of Boc-Protected N-Methylamines with IOAc as the Oxidant: A Boc-Directed sp3 C-H Bond Activation

Dong-Hui Wang, Xue-Shi Hao, Di-Fu Wu and Jin-Quan Yu*

*Department of Chemistry MS015, Brandeis University, Waltham, Massachusetts 02454-9110, Email:

D.-H. Wang, X.-S. Hao, D.-F. Wu, J.-Q. Yu, Org. Lett., 2006, 8, 3387-3390.

DOI: 10.1021/ol061384m


Pd-catalyzed selective oxidation of Boc-protected N-methylamines with IOAc as the oxidant involves a Boc-directed C-H activation process.

see article for more examples

Key Words

1,2-amino alcohols, tert-butyl carbamates, iodosobenzene diacetate

ID: J54-Y2006-2210