Palladium-Catalyzed Oxidation of Boc-Protected N-Methylamines with IOAc as the Oxidant: A Boc-Directed sp³ C-H Bond Activation

Dong-Hui Wang, Xue-Shi Hao, Di-Fu Wu and Jin-Quan Yu*

*Department of Chemistry MS015, Brandeis University, Waltham, Massachusetts 02454-9110, Email: yu200brandeis.edu

D.-H. Wang, X.-S. Hao, D.-F. Wu, J.-Q. Yu, Org. Lett., 2006, 8, 3387-3390.

DOI: 10.1021/ol061384m

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Abstract

Pd-catalyzed selective oxidation of Boc-protected N-methylamines with IOAc as the oxidant involves a Boc-directed C-H activation process.

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Key Words

1,2-amino alcohols, tert-butyl carbamates, iodosobenzene diacetate

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ID: J54-Y2006-2210