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Gold-Catalyzed Highly Efficient Access to 3(2H)-Furanones from 2-Oxo-3-butynoates and Related Compounds

Yuanhong Liu,* Meina Liu, Shenghai Guo, Huamin Tu, Yebing Zhou and Hongjun Gao

*State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences,354 Fenglin Lu, Shanghai 200032, People's Republic of China, Email: yhliumail.sioc.ac.cn

Y. Liu, M. Liu, S. Guo, H. Tu, Y. Zhou, H. Gao, Org. Lett., 2006, 8, 3445-3448.

DOI: 10.1021/ol061059z (free Supporting Information)


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Abstract

Gold-catalyzed cyclizations of 2-oxo-3-butynoic esters or disubstituted-1,2-diones with a variety of nucleophiles offer an efficient and straightforward route to substituted 3(2H)-furanones under mild reaction conditions.

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Key Words

3(2H)-Furanones, 2-Oxo-3-butynoates


ID: J54-Y2006-2230