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Silica-Supported Perchloric Acid (HClO4-SiO2): A Versatile Catalyst for Tetrahydropyranylation, Oxathioacetalization and Thioacetalization

Abu T. Khan*, Tasneem Parvin, Lokman H. Choudhury

*Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781 039, India, Email:

A. T. Khan, T. Parvin, L. H. Choudhury, Synthesis, 2006, 2497-2502.

DOI: 10.1055/s-2006-942465


A simple and convenient synthetic protocol for the protection of hydroxyl groups as tetrahydropyranyl ethers as well as carbonyl functionalities as oxathioacetals and thioacetals has been achieved using a catalytic amount of silica-supported perchloric acid under solvent-free conditions.

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Key Words

alcohols, phenols, THP ethers, carbonyl compounds, oxathioacetals, thioacetals

ID: J66-Y2006-2240