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A Convenient Synthesis of 4-Alkyl-5-aminoisoxazoles

Matthew P. Bourbeau* and James T. Rider

*Department of Medicinal Chemistry, Amgen Inc., 1 Amgen Center Drive, Thousand Oaks, California 91303, Email: bourbeauamgen.com

M. P. Bourbeau, J. T. Rider, Org. Lett., 2006, 8, 3679-3680.

DOI: 10.1021/ol061260+ (free Supporting Information)


Abstract

A series of 4-alkyl-5-aminoisoxazoles have been synthesized in high yield by nucleophilic addition of lithiated alkyl nitriles to (α)-chlorooximes.

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Key Words

Isoxazoles


ID: J54-Y2006-2420