New Efficient Organic Activators for Highly Enantioselective Reduction of Aromatic Ketones by Trichlorosilane
Yoshihiro Matsumura,* Kanako Ogura, Yoshimi Kouchi, Fumiaki Iwasaki and Osamu Onomura
*Graduate School of Biomedical Sciences, Nagasaki University,Bunkyo-machi,
Nagasaki 852-8521, Japan, Email: matumura
net.nagasaki-u.ac.jp
Y. Matsumura, K. Ogura, Y. Kouchi, F. Iwasaki, O. Onomura, Org. Lett., 2006, 8, 3789-3792.
DOI: 10.1021/ol0613822
Abstract
Aryl ketones were reduced to the corresponding alcohols with excellent enantioselectivity by trichlorosilane in the presence of a catalytic amount of N-formyl-α'-(2,4,6-triethylphenyl)-L-proline as an activator.
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Key Words
reduction of ketones, trichlorosilane, organocatalysis
ID: J54-Y2006-2480
