Construction of Tetrasubstituted Carbon by an Organocatalyst: Cyanation Reaction of Ketones and Ketimines Catalyzed by a Nucleophilic N-Heterocyclic Carbene
Yoshimasa Fukuda, Kazuhiro Kondo*, Toyohiko Aoyama*
*Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan, Email: kazukphar.nagoya-cu.ac.jp, aoyamaphar.nagoya-cu.ac.jp
Y. Fukuda, K. Kondo, T. Aoyama, Synthesis, 2006, 2649-2652.
DOI: 10.1055/s-2006-942483
Abstract
An N-heterocyclic carbene as a nucleophilic organocatalyst allows the cyanation of ketones and ketimines with TMSCN in good yields under mild reaction conditions.
see article for more examples
Key Words
N-heterocyclic carbene, tetrasubstituted carbon, nucleophilic organocatalyst, organocatalysis, cyanation (ketones, imines), trimethylsilyl cyanide
ID: J66-Y2006-2520